The quasi-neoplastic nodular palmar fibromatosis [] called Dupuytren's disease (DD) often causes permanent flexion contracture of the metacarpophalangeal and proximal interphalangeal joints of the digits [2,3] (Figure (Figure1), 1), leading to loss of function, deformity of the hand, and permanent contracture of the involved digits [2,4]. James Barrie, author of "Peter Pan" had a right contracture thought to be Dupuytren's, which formed the source material for Captain Hook's hook. Edinburgh: Churchill Livingstone; 1990. Dupuytren contracture is characterized by a deformity of the hand in which the joints of one or more fingers cannot be fully straightened (extended); their mobility is limited to a range of bent (flexed) positions. INTRODUCTION. DD commonly occurs in individuals of northern European extraction. Clin Genet, 68 (2005), pp. The most affected fingers are usually the ring finger, middle finger, and pinkie. The hand and upper limb series. 1 Epidemiological reports show that this condition predominantly affects . Dupuytren's disease (DD) is an ancient affliction of unknown origin. . Thickening and contraction of the palmar fascia (Dupuytren's contracture) associated with . Summerskill WH, Wolfe SJ. Also commonly affects the little finger, and rarely the middle finger. It predominantly affects elderly, male caucasians, has a hereditary predisposition and has strong associations with diabetes, alcohol consumption . Dupuytren's Contracture is a progressive flexion deformity of the fingers, typically affecting the 4 th (ring) finger. Dupuytren's contracture is a benign disease with an abnormal fibroblast proliferation process and unclear pathogenesis. Cellular components and processes associated with DD pathogenesis include altered gene and protein expression of cytokines, growth factors, adhesion molecules, and extracellular matrix components . On the origin and spread of Dupuytren's dis-ease (review). As a result, the person's fingers look like they're being pulled inward. Dupuytren's contracture is not a life-threatening condition, and the nodules are not cancerous. . Long ago, in the sixteenth century in Scotland, the chieftains of Clan MacLeod were chieftains of the Island of Skye. The cause is not known. 424-429. Dupuytren's contracture is rare in people of African Middle Eastern descent, 2 but is common among Caucasians, particularly the Scottish, and hence the legendary "Curse of the Mac Crimmons." 3 The Mac Crimmons family ran the college of bagpiping in Scotland from the 15th to the 18th century. Dupuytren's Contracture is a hand deformity. Dupuytren disease (DD) is a fibrosing disorder that results in slowly progressive thickening and shorting of the palmar fascia and leads to debilitating digital contractures, particularly of the metacarpophalangeal (MCP) joints or the proximal interphalangeal (PIP) joints. Dupuytren's contracture in the negro - case report. On the origin and spread of Dupuytren's disease. Mapping of an autosomal dominant gene for Dupuytren's contracture to chromosome 16q in a Swedish family. Eventually, the lumps, or nodules, may grow . Article Download PDF View Record in Scopus Google Scholar. J Hand Surg1979: 451, 5. It will be shown that the age distribution reflects certain general characteristics exhibited by diseases that are widely believed to have a spontaneous, disturbed-tolerance auto-immune etiology, including Dupuytren's contracture. Dupuytren's contracture, also known as Dupuytren's disease, is a hand deformity that causes the tissue beneath the surface of the hand to thicken and contract. While the index may be affected as well, the disease rarely reaches . nlm.nih.gov/12015711) • Michou L, Lermusiaux JL, Teyssedou JP, Bardin T, Beaudreuil J, Petit-Teixeira E. Genetics of Dupuytren's disease. This condition usually affects the fourth and fifth . It happens very gradually as soft tissue under the skin starts knotting. The first author to suggest an origin and spread of Dupuytren's disease was Early who wrote in 1962, "If one postulates the condition as having arisen in one particular racial group (the Nordic for example) then the variable distribution in other parts of the world might be explained on the basis of migration from that group." Dupuytren's disease: biology and treatment, Vol 5. This suggests that these share a common genetic origin, or possibly are simply different faces of one disease. Dupuytren's contracture is a deforming, fibrotic condition of the palmar fascia which has confounded clinicians and scientists since the early descriptions by Guillaume Dupuytren in 1831. Practice Essentials. De ziekte van Dupuytren is een zogeheten goedaardige fibromatose (woekering van het bindweefsel) van de hand en vingers, die vaak leidt tot een kromstand van de vingers. There are many stories as to how the curse arose. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and . Plater, 1614; Dupuytren, 1831. It is a result of contracture and fibrosis of the palmar aponeurosis. 4. It is often cited as being of genetic origin (hereditary). Dupuytren's contracture is now known to have a genetic basis, and in certain (Caucasian) populations it is a rather common chronic disease (Early 1962, Hueston 1963 . Mennen U, Gräbe RP. Deze kennis zou . Dupuytren's disease (DD) is an ill-defined fibroproliferative disorder of the palm of the hands leading to digital contracture. Introduction. J Hand Surg [Am]2002; 27: 385-390. . The Papal . Dupuytren's contracture prevented the affected . Some say that the MacCrimmons were cursed by a widow whose only son was . It is defined by Dorland as shortening, thickening, and fibrosis of the palmar fascia producing a flexion deformity of a finger. For example, people with a family history of Dupuytren disease are more likely to develop Ledderhose disease. There is myofibroblast proliferation which results in altered collagen . McFarlane RM. However, what happens over time can be discomforting. 3. Definition. .nlm.nih.gov/21803632) • Rodrigues JN, Becker GW, Ball C, Zhang W, Giele H, Hobby J, Pratt AL, Davis T. Surgery for Dupuytren's . Circumscribed connective tissue induration of the palmar aponeurosis with bending contracture of the fingers. Pendant on the sole of the foot plantar fibromatosis (Ledderhose syndrome), see also polyfibromatosis. CrossRef View Record in Scopus Google Scholar Een deels genetische ontstaanswijze voor de ziekte wordt verondersteld. Introduction. PDF | On Jan 15, 2013, Aditya Sood and others published Dupuytren's Contracture | Find, read and cite all the research you need on ResearchGate Dupuytren's Contracture is a condition that causes a thickening of the fibrous tissue layer underneath the skin of the palm and fingers and leads to the inability to straighten the fingers. 385-390. The condition is a disorder of connective tissue, which supports the body's muscles, joints, organs, and skin and provides strength and flexibility to structures throughout the body. Request PDF | Microarray Gene Analysis and Expression Profiles of Dupuytren's Contracture | Dupuytren's disease, although not altogether uncommon, has eluded scientists who have sought to . . Abstract. Dupuytren's contracture (English) Origin & history Named after Baron Guillaume Dupuytren, the surgeon who described a corrective operation for the affliction in the Lancet in 1831. Section snippets Genetic Predisposition. Evidence of Dupuytren's . A fixed flexion contracture of the hand where the fingers bend towards the palm and cannot be fully extended Dupuytren's disease (DD) is a fibro-proliferative disorder characterized by progressive palmar fascia fibrosis 1-3 with a variable prevalence among racial groups and an increased incidence in males of Northern European ancestry. 1, 2 Despite known risk factors, the pathogenesis of DD remains unclear.. Palmer fascia fibrosis in DD causes progressive fixed flexion contracture . Noun Dupuytren's contracture. A history of Dupuytren's Contracture. Second only to the MacLeods were their pipers, the MacCrimmons. The ulnar fingers are usually most . Dupuytren disease has been referred to as a Viking or Celtic disease, but existed in Europe earlier than the Viking Age 8345270 and originated much earlier in prehistory 12015711 . This section has been translated automatically. Het doel van dit proefschrift was het onderzoeken van de genetische achtergrond van de ziekte van Dupuytren en vergelijkbare fibromatosen. On the origin and spread of Dupuytren's disease. J Hand Surg Am, 27 (2002), pp.
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